Table 3 Summary of meta-analysis of association of CDKAL1 gene rs7756992 A/G gene polymorphism and type 2 diabetes mellitus (T2DM) in the Asian subgroup

From: CDKAL1 gene rs7756992 A/G polymorphism and type 2 diabetes mellitus: a meta-analysis of 62,567 subjects

Genetic model

Pooled OR (95% CI)

Z value

P value

Study number

T2DM size

control size

P heterogeneity( I2%)

Allelic genetic model

1.190(1.110–1.270)

5.09

3.58 × 10−7*

12

16765

16602

<0.0001* (73.3%)

Subgroup 1:GG1 > 200

1.240(1.180–1.290)

9.70

2.85 × 10−22*

6

11973

12016

0.23(27.4%)

Subgroup 2:GG1 < 200

1.120(0.970–1.300)

1.53

0.13

6

3792

4586

0.0004* (78.0%)

Recessive genetic model

1.570(1.360–1.800)

6.26

3.85 × 10−10*

12

16765

16602

<0.00001* (81.9%)

Subgroup 1:GG1 > 200

1.670(1.510–1.840)

10.16

4.52 × 10−24*

6

11973

12016

0.03* (58.7%)

Subgroup 2:GG1 < 200

1.470(1.030–2.100)

2.12

0.03*

6

3792

4586

<0.00001* (86.9%)

Dominant genetic model

1.173(1.068–1.289)

3.33

8.68 × 10−4*

12

16765

16602

<0.00001* (67.2%)

Subgroup 1:AA0 > 300

1.229(1.123–1.346)

4.46

8.20 × 10−6*

6

12698

12725

0.033* (58.8%)

Subgroup 2::AA0 < 300

1.088(0.886–1.335)

0.81

0.421

6

4067

3877

0.004* (70.7%)

Homozygous genetic model

1.404(1.237–1.594)

5.25

1.52 × 10−7*

12

16765

16602

<0.00001* (70.9%)

Subgroup 1:GG1 > 200

1.511(1.407–1.624)

11.30

7.42 × 10−27*

6

11973

12016

0.234(26.7%)

Subgroup 2:GG1 < 200

1.272(0.938–1.725)

1.55

0.121

6

3792

4586

<0.00001* (77.6%)

Heterzygous genetic model

1.078(0.990–1.174)

1.74

0.083

12

16765

16602

0.012* (54.6%)

Subgroup 1:AA0 > 300

1.114(1.022–1.215)

2.46

0.014*

6

12698

12725

0.086(48.2%)

Subgroup 2::AA0 < 300

1.010(0.839–1.217)

0.11

0.914

6

4067

3877

0.028* (60.2%)

  1. *P < 0.05.
  2. Abbreviations: T2DM: type 2 diabetes mellitus; CI: confidence interval; OR: odds ratio; T2DM size: the total number of T2DM cases; control size: the total number of control group; Allelic genetic model: G allele distribution frequency; recessive genetic model: GG vs. AA + AG; Dominant genetic model: AG + GG vs. AA; Homozygous genetic mode: GG vs. AA; Heterzygous genetic model: AG vs. AA; Additive genetic model. total G allele vs. total A allele.
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