Figure 3

The protective effects of piceatannol, a Syk inhibitor, on infarction and swelling at 22 h after reperfusion following 2 h ischemia.

Brains were removed and the forebrains were sliced into 5 coronal 2-mm sections. Sections are identified according to the distance from the frontal limit of the forebrain. (A) A representative photograph of TTC staining of 8-mm front coronal brain sections (2 mm thick) at 22 h after reperfusion following 2 h ischemia. The upper panel is vehicle control and the lower panel is piceatannol treatment (at 100 mg/kg × 2, i.p.). Pre- and post-treatments with piceatannol (B) at 50 and 100 mg/kg significantly reduced the infarct area and that with piceatannol (C) at 100 mg/kg significantly reduced the infarct volume. (D) Piceatannol at 50 and 100 mg/kg significantly reduced swelling. * P < 0.05, ** P < 0.01 vs. vehicle, n = 8–10.