Figure 4

The mechanisms of the protective effects of piceatannol after cerebral ischemia.

Quantitative analysis with western blot shows that the expression level of (A) p-Syk was increased at 22 h after reperfusion and administration of piceatannol intraperitoneally at 50 and 100 mg/kg, i.p. significantly reduced p-Syk. (B) ICAM1 was increased after 22 h after reperfusion and administration of piceatannol intraperitoneally at 100 mg/kg, i.p. significantly reduced ICAM1. (C) MMP9 was increased 22 h after reperfusion and administration of piceatannol intraperitoneally at 100 mg/kg, i.p. significantly reduced MMP9. (D) Claudin5 expression was decreased after 22 h after reperfusion and administration of piceatannol intraperitoneally at 100 mg/kg, i.p. significantly ameliorated Claudin5 expression. Cropped blots are used in the figure. These gels were run under same experimental condition. ^# P < 0.05 vs. control, * P < 0.05, ** P < 0.01 vs. vehicle, n = 6.