Figure 1

Minute autonomous biodevice for minimally invasive neuron interfacing.
Conceptual scheme of a wireless, self-powered biodevice for detection of neuronal signals which enables in vivo neurophysiological studies on a sub-cellular level with minimal intrusion and leads to a new generation of brain device interfaces. The images of a light emitting nanodiode, a nanotransistor and a single neuron were adopted from Ref. 6, 8, 56. The structure of BOx was visualised based on the know crystal structure (PDB 2XLL) and CDH was designed using the cytochrome and the FAD domains of Phanerochaete chrysosporium cellobiose dehydrogenase (PDB 1D7D and 1NAA), respectively.