Table 1 SOD1 dissociation constants as determined by native mass spectrometry. The dissociation constants are means ± standard error from 3 distinct data sets with each containing 5 data points (see supplementary figure 4)

From: Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis

Variant

WT

A4V

G37R

H46R

D90A

G93A

V148G

SOD1 KD (nM)

9 ± 1

1100 ± 100

10 ± 1

30 ± 4

25 ± 4

12 ± 1

271 ± 40

GS-SOD1 KD (nM)

34 ± 5

9600 ± 900

60 ± 9

97 ± 16

-

160 ± 32

-