Table 1 SOD1 dissociation constants as determined by native mass spectrometry. The dissociation constants are means ± standard error from 3 distinct data sets with each containing 5 data points (see supplementary figure 4)
Variant | WT | A4V | G37R | H46R | D90A | G93A | V148G |
|---|---|---|---|---|---|---|---|
SOD1 KD (nM) | 9 ± 1 | 1100 ± 100 | 10 ± 1 | 30 ± 4 | 25 ± 4 | 12 ± 1 | 271 ± 40 |
GS-SOD1 KD (nM) | 34 ± 5 | 9600 ± 900 | 60 ± 9 | 97 ± 16 | - | 160 ± 32 | - |