Table 2 Top functional genes in Caco-2 cells associated with host-bacterial interaction
From: Cross-talk between E. coli strains and a human colorectal adenocarcinoma-derived cell line
| Â | Mean Fold Change | Â | Â | |||||
|---|---|---|---|---|---|---|---|---|
| Â | Caco-2 incubated with E. coli K-12 | Caco-2 incubated with E. coli O157:H7 | Â | Â | ||||
Symbol | 60 min | 90 min | 120 min | 60 min | 90 min | 120 min | Location | Type(s) |
CXCL1 | 1.433 | 1.456 | 1.473 | 1.573 | 1.679 | 1.650 | Extracellular Space | cytokine |
CXCL2 | 1.738 | 1.885 | 1.848 | 1.877 | 2.026 | 1.953 | Extracellular Space | cytokine |
CXCL3 | 1.415 | 1.424 | 1.486 | 1.531 | 1.613 | 1.646 | Extracellular Space | cytokine |
GADD45B | 1.358 | 1.400 | 1.532 | 1.242 | 1.374 | 1.474 | Cytoplasm | other |
JUN | 1.297 | 1.459 | 1.517 | 1.312 | 1.504 | 1.583 | Nucleus | transcription regulator |
MED17 | −1.292 | −1.254 | −1.309 | −1.282 | −1.308 | −1.332 | Nucleus | transcription regulator |
MYL12A | 1.214 | 1.391 | 1.473 | 1.218 | 1.475 | 1.501 | unknown | other |
PPIA | −1.684 | −1.419 | −1.480 | −1.450 | −1.737 | −1.498 | Cytoplasm | enzyme |
RCAN1 | 1.581 | 1.503 | 1.515 | 1.648 | 1.623 | 1.638 | Nucleus | transcription regulator |
SOD2 | 2.404 | 2.714 | 2.587 | 2.352 | 3.170 | 3.054 | Cytoplasm | enzyme |
GTF2A2 | −1.346 | −1.306 | −1.329 | −1.266 | −1.275 |  | Nucleus | transcription regulator |
TNFAIP3 | 1.215 | -- | 1.254 | 1.297 | 1.239 | 1.407 | Nucleus | enzyme |
TRIM25 | −1.230 | −1.293 | −1.282 | -- | −1.262 | −1.331 | Cytoplasm | transcription regulator |
HGD | -- | 1.241 | 1.206 | -- | 1.241 | 1.328 | Cytoplasm | enzyme |
FOS | -- | 1.396 | 1.444 | -- | 1.387 | 1.418 | Nucleus | transcription regulator |
FARSB | -- | −1.201 | −1.243 | -- | −1.324 | −1.223 | Cytoplasm | enzyme |
CDK5R1 | -- | −1.382 | −1.468 | -- | −1.340 | −1.642 | Nucleus | kinase |
CNOT7 | −1.205 | −1.254 | -- | -- | −1.251 | −1.309 | Nucleus | transcription regulator |
HDAC4 | −1.290 | −1.258 | -- | −1.215 | −1.245 | -- | Nucleus | transcription regulator |
HIPK2 | −1.262 | -- | -- | −1.217 | −1.278 | −1.216 | Nucleus | kinase |
GNAS | −1.211 | −1.236 | −1.275 | -- | -- | −1.223 | Plasma Membrane | enzyme |
KLF4 | −1.289 | −1.291 | −1.328 | -- | -- | −1.243 | Nucleus | transcription regulator |
USP42 | −1.240 | −1.200 | −1.250 | −1.254 | -- | -- | unknown | peptidase |
VAPA | −1.349 | −1.375 | −1.373 | −1.323 | -- | -- | Plasma Membrane | other |
MED13 | −1.325 | −1.365 | -- | −1.219 | −1.291 | -- | Nucleus | transcription regulator |
NFIC | −1.218 | −1.290 | -- | −1.255 | −1.263 | -- | Nucleus | transcription regulator |
SKI | −1.219 | −1.213 | -- | −1.270 | −1.206 | -- | Nucleus | transcription regulator |
SYNJ2 | −1.242 | −1.432 | -- | −1.204 | −1.451 | -- | Cytoplasm | phosphatase |
ACVR1B | −1.208 | −1.204 | -- | −1.212 | -- | -- | Plasma Membrane | kinase |
IL1A | −1.211 | −1.277 | -- | −1.340 | -- | -- | Extracellular Space | cytokine |
IGF1R | −1.247 | −1.226 | -- | −1.251 | -- | -- | Plasma Membrane | transmembrane receptor |
TRAF3 | −1.227 | −1.213 | -- | -- | −1.209 | -- | Cytoplasm | other |
ADRB1 | -- | −1.326 | -- | -- | −1.266 | −1.269 | Plasma Membrane | G-protein coupled receptor |
TNS1 | -- | −1.212 | -- | −1.235 | −1.228 | -- | Plasma Membrane | other |
BTG2 | -- | -- | 1.224 | -- | 1.345 | 1.361 | Nucleus | transcription regulator |
MAVS | -- | -- | −1.223 | -- | −1.203 | −1.232 | Cytoplasm | other |
CCL20 | -- | -- | -- | 1.445 | 1.554 | 1.375 | Extracellular Space | cytokine |
IL8 | -- | -- | -- | 1.482 | 1.614 | 1.637 | Extracellular Space | cytokine |
EIF3B | -- | −1.326 | −1.222 | -- | -- | −1.351 | Cytoplasm | translation regulator |
SOS1 | -- | −1.211 | −1.421 | -- | -- | −1.401 | Cytoplasm | other |
HSD3B1 | -- | −1.322 | −1.283 | -- | −1.305 | -- | Cytoplasm | enzyme |
NOC2L | -- | −1.308 | −1.235 | -- | −1.501 | -- | Nucleus | transcription regulator |
ELAVL1 | −1.227 | -- | -- | −1.202 | −1.240 | -- | Cytoplasm | other |
TLK1 | −1.227 | -- | -- | −1.219 | −1.258 | -- | Cytoplasm | kinase |
RDH13 | −1.208 | -- | -- | −1.236 | −1.229 | -- | Cytoplasm | enzyme |
SLC7A1 | −1.214 | -- | −1.215 | −1.222 | -- | -- | Plasma Membrane | transporter |
HIST1H1E | 1.339 | 1.238 | 1.427 | -- | -- | -- | Nucleus | other |
HS3ST1 | -- | -- | −1.242 | −1.212 | -- | −1.297 | Cytoplasm | enzyme |
