Figure 1
Plasma and CSF kinetics of oxytocin (OXT) administered intranasally at a dose of 24 IU.
(A) Shown are OXT plasma concentrations (mean ± SD) immediately before (baseline, 0 min) and after intranasal OXT or placebo (PLC) treatment. OXT plasma concentrations reached a plateau after 15 min and decreased after 60 min. Given for each time point in this period is the percentage increase (corrected for the lowest OXT concentration at 0 min) over PLC mean (0–90 min). (B) Shown are oxytocin (OXT) cerebrospinal fluid (CSF) concentrations following intranasal oxytocin (OXT) or placebo (PLC) treatment. CSF levels took up to 75 min to reach a significantly increased level in the OXT group. Given is the percentage increase (corrected for the lowest OXT concentration at 45 min) over PLC mean (45–75 min). Abbreviation: cOXT, oxytocin concentration.
