Table 3 Prediction of eriocitrin mechanism using SNEA
From: Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis
Gene set seed | Name | Total # of neighbours | # of measured neighbours | Measured neighbours | Median change | P value |
|---|---|---|---|---|---|---|
RXR | Retinoid X receptor | 248 | 68 | APOA4, VEGFA, DDAH1, LCN2, FGFR1, CAV1, SCARB1, ABCC2, CYP27A1, FGB, HMOX1, MGP, ACOX1, CA2, NR1D1, ARG2, CYP8B1, VDR, ABCG5, LPL, CEBPA, PTPN6, RBP1, APOA1, CETP, DBI, FOS, MYOD1, ANGPTL3, THRB, BCL2, EGFR, BCL2L1, NDRG1, SLC2A2, ACADM, SLC27A2, ACLY, ACO1, PTH1R, CYP4A11, FABP1, GATA6, MEIS1, RXRG, COL1A2, PLIN2, SCP2, SLC27A1, CRABP1, CYBB, DUSP1, CCND1, ACACB, TRIB3, CYBA, ANGPTL4, ABCA1, NR1H4, NR1H3, HAND2, LDLR, SLC13A1, MAF, DCN, EGR1, RETN, SLC26A5 | −1.017 | 0.004 |
SREBF1 | Sterol regulatory element binding transcription factor 1 | 134 | 50 | SLC2A2, CAV1, PTGDS, CEBPB, ABCA1, FABP1, CETP, ACSS2, HMGCS1, DBI, LPIN1, IRS2, PFKFB1, ACACB, ALDH1A2, INSIG1, VEGFA, PKLR, PDX1, SLC27A2, FDPS, HK2, RETN, ACLY, FADS2, ELOVL5, HMOX1, LPL, AR, HNF4A, LIPE, LIPC, CYP8B1, ACSL1, GNAI2, GPX3, PGD, CASP2, IDH1, HSD17B7, COL6A1, TRIB3, DHCR7, GPAM, SP1, HDC, LDLR, SCARB1, BAX, CEBPA | −1.055 | 0.005 |
STAT6 | Signal transducer and activator of transcription 6 | 119 | 20 | CAV1, BCL2, BAX, IGFBP1, COL1A2, BCL2L1, AICDA, AGT, IRS2, SOCS3, MUC5AC, IGF1, CDKN1B, MUC1, CLCA1, EGR1, MAF, PML, VCAM1, NFIL3 | −1.450 | 0.006 |
CDX2 | Caudal type homeobox 2 | 64 | 11 | IRS2, HNF1A, CDH17, FABP2, HNF4A, VDR, ACAT2, SP1, HBEGF, LYPLA1, BCL2 | 1.328 | 0.007 |
MAPK11 | Mitogen-activated protein kinase 11 | 36 | 11 | SCARB1, BAX, BCL2, HMOX1, VDR, CEBPD, PRDX1, CAV1, CEBPB, EGR1, CCND1 | 1.025 | 0.007 |
Luteinizing hormone | - | 69 | 15 | LDLR, SCARB1, EGFR, AREG, CEBPD, RETN, C13orf15, KDR, IGFBP5, ANXA5, FLT1, IGFBP2, SGK1, PSEN1, CEBPB | −1.238 | 0.007 |
NKX2-5 | NK2 homeobox 5 | 52 | 14 | CALR, TLL1, CTNNB1, GATA4, PITX2, ACTC1, DIO2, MEF2A, ACACB, T, PLOD1, MYOD1, HOPX, ACTA2 | −1.360 | 0.008 |
HEY1 | Hairy/enhancer-of-split related with YRPW motif 1 | 23 | 11 | MDM2, RUNX2, ID1, ACTA2, KDR, GATA4, GATA6, MYF5, OCLN, AR, PRODH2 | −1.342 | 0.008 |
Runt | Runt-related transcription factor | 50 | 9 | BCL2, C13orf15, LGALS3, CEBPD, TGFBR1, BTG2, SP1, IL7R, RUNX2 | −1.368 | 0.009 |
