Table 1 KEGG pathway enrichment analysis of genes with increased (ΔS > 0) and decreased (ΔS < 0) entropy. The enrichment p-value is from a modified Fisher's Exact Test (EASE Score) and then corrected for multiple hypothesis testing by calculating false discovery rate (FDR). The common enrichment pathways among genes with altered entropy in H5N1 and H1N1 infections were considered and the maximum of the two FDRs was shown. The threshold for FDR was set to 0.05. ‘-’ indicates no enrichment
From: Characterizing and controlling the inflammatory network during influenza A virus infection
KEGG pathway | FDR (ΔS > 0) | FDR (ΔS < 0) | Representative genes |
|---|---|---|---|
TLRs signaling | 1.10E-23 | 0.9 | TNFα, TOLLIP, NFκB1, TLR4, IFNB1 |
CCR interaction | 3.02E-22 | 1 | CCR1, CXCL10, CXCR4, CCR7, CCR3 |
Chemokine signaling | 3.33E-13 | - | CCL2, CCR1, NFκB1,CXCL10, CXCR4 |
NLRs signaling | 4.95E-10 | - | NLRP3, NOD1, MEFV, MAPK14, RIPK2 |
Cytosolic DNA-sensing | 0.002 | - | IFNB1, PYCARD, NFκB1, IKBKB, CCL5 |
TCR signaling | 0.003 | 94.7 | FOS, IKBKB, NFκB1, NFATC4, MAPK14 |
