Table 1 Top 6 Functions of SAHA-PIP modulated genes
SAHA-PIP | Functions Annotation (p-Value) |
|---|---|
1 | Glucose Metabolism Disorder (9.72E-05), Quantity Of Bilirubin (1.22E-04), Diabetes Mellitus (1.55E-04), Familial Hyperaldosteronism (3.18E-04), Synthesis Of Triacylglycerol (4.26E-04), Lung Tumor (5.04E-04) |
2 | Angina Pectoris (1.04E-04), Olfactory Response Of Organism (1.28E-04), Lamellar Ichthyosis (1.62E-04), Bodily Balance (1.95E-04), Efflux Of L-Glutamic Acid (8.57E-04), Hyperplasia Of Stroma (8.57E-04) |
3 | Metabolism Of 9-Cis-Retinoic Acid (5.46E-06), Cytolysis Of Antigen Presenting Cells (8.56E-06), Cytolysis Of Phagocytes (2.12E-05), Expansion Of Tumor Cell Lines (2.50E-05), Metabolism Of Retinoid (4.40E-05), Cytolysis Of Fibroblast Cell Lines (7.28E-05) |
4 | Degeneration Of Cholinergic Neurons (6.89E-06), Priming Of Cells (1.52E-05), Quantity Of Striatal Neurons (1.91E-05), Glucose Metabolism Disorder (3.77E-05), Growth Of Perikaryon (5.01E-05), Reduction Of Cholesterol (5.01E-05) |
5 | Uterine Cancer (3.56E-07), Uterine Serous Papillary Cancer (1.34E-06), Endometrial Cancer (2.33E-06), Abnormal Morphology Of Xiphoid Process (6.81E-06), Endometrial Carcinoma (6.85E-06), Uterine Tumor (8.90E-06) |
6 | Uterine Cancer (4.05E-05), Endometrial Carcinoma (4.46E-05), Lamellar Ichthyosis (1.30E-04), Cervical Carcinoma (2.38E-04), Abnormal Morphology Of Melanosomes (2.49E-04), Aggregation Of Melanoma Cell Lines (2.49E-04) |
7 | Formation Of Endothelial Tube (8.31E-05), Morphology Of Radius (2.17E-04), Morphology Of Anterior Pituitary Cells (2.25E-04), Formation Of Endothelial Cells (2.61E-04), Formation Of Epithelial Tissue (5.94E-04), Anodontia (7.56E-04) |
8 | Development Of Terminal End Bud (4.32E-06), Endometrial Carcinoma (1.19E-05), Uterine Cancer (1.40E-05), Lung Development (1.43E-05), Contraction Of Myofiber (2.90E-05), Transmigration Of Cancer Cells (2.90E-05) |
9 | Uterine Serous Papillary Cancer (7.02E-08), Endometrial Cancer (8.78E-07), Formation Of Tight Junctions (7.02E-06), Morphogenesis Of Gastrointestinal Tract (7.02E-06), Differentiation Of Cells (7.14E-06), Uterine Cancer (7.32E-06) |
10 | Stimulation Of Lymphatic System Cells (9.85E-05), Th2 Immune Response Of Natural Killer T Lymphocytes (1.96E-04), Reduction Of Cholesterol (1.96E-04), Activation Of Ganglion Cells (3.03E-04), Growth Of Nervous Tissue (3.03E-04), Binding Of Interferon-Gamma Activated Sequence (3.77E-04) |
11 | Conversion Of Cerivastatin (7.37E-05), Lysis Of Liposome (7.37E-05), Metabolism Of Cerivastatin (7.37E-05), Neurogenesis Of Subventricular Zone (1.30E-04), Catabolism Of Cyclic AMP (1.68E-04), Killing Of Hematopoietic Cells (1.68E-04) |
12 | Hyperplasia Of Stroma (6.57E-05), Morphology Of Anterior Pituitary Cells (2.18E-04), Antibody-Dependent Cell-Mediated Cytotoxic Reaction Of Cells (4.54E-04), Absorption Of Ca2+ (9.64E-04), Ploidy Of Hepatocytes (1.17E-03), Quantity Of Lactotropes (1.41E-03) |
13 | Cell-Cell Adhesion Of Neurons (1.45E-05), Self-Administration Of Cocaine (4.43E-05), Self-Administration (4.73E-05), Abnormal Morphology Of Aorta (6.02E-05), Lung Adenocarcinoma (2.14E-04), Binding Of Cellular Membrane (2.44E-04) |
14 | Lung Adenocarcinoma (6.66E-06), Bipolar Disorder (8.85E-06), Lung Tumor (1.24E-05), Lung Cancer (1.35E-05), Carcinoma In Lung (2.79E-05), Morphology Of Anterior Pituitary Cells (3.80E-05) |
15 | Cocaine-Related Disorder (7.35E-06), Malignant Hypertension (9.93E-06), Lung Cancer (1.09E-05), Lung Adenocarcinoma (1.15E-05), Adenocarcinoma (1.43E-05), Carcinoma In Lung (4.30E-05) |
16 | Uptake Of Retinoid (4.21E-04), Metabolism Of D-Fructose (6.29E-04), Signaling Of Inositol Phosphate (6.29E-04), Absorption Of Phosphate (8.77E-04), Development Of Diaphragm (1.49E-03), Proliferation Of Cerebral Cortex Cells (3.69E-03) |
17 | Progression Of Atherosclerotic Lesion (1.20E-04), Lung Tumor (4.48E-04), Neuritogenesis Of Pheochromocytoma Cell Lines (4.76E-04), Mitogenesis Of Skin Cell Lines (5.02E-04), Pachyonychia Congenital (5.02E-04), Lung Cancer (6.12E-04) |
18 | Fibrosis Of Muscle (1.83E-05), Concentration Of Lipid (8.60E-05), Crohn's Disease (1.87E-04), Fibrosis Of Skeletal Muscle (2.26E-04), Mass Of Liver (2.42E-04), Inflammation Of Intestine (4.67E-04) |
19 | Shape Change Of Skin Cancer Cell Lines (8.85E-05), Nonsyndromic Hearing Impairment (1.72E-04), Length Of Filaments (2.20E-04), Development Of Inner Ear (5.79E-04), Release Of Neurotransmitter (6.18E-04), Cell Death Of Neural Stem Cells (8.68E-04) |
20 | Quantity Of Monoamines (6.48E-05), Quantity Of Catecholamine (2.17E-04), Olfaction (2.28E-04), Abnormal Morphology Of Lung (2.91E-04), Peroxidation Of Lipid (3.49E-04), Development Of Cecum (3.77E-04) |
21 | Carpal Tunnel Syndrome (3.82E-05), Formation Of Calvaria (4.82E-05), Abnormal Morphology Of Dilated Distal Convoluted Tubule (1.44E-04), Modification Of Octanoic Acid (.44E-04), Sick Sinus Syndrome (2.87E-04), Morphogenesis Of Muscle (3.16E-04) |
22 | Chemotaxis Of Lymphatic Endothelial Cells (1.09E-04), Isomerization Of Lipid (1.09E-04), Regeneration Of Gastrocnemius (1.09E-04), Pyroptosis Of Bone Marrow-Derived Macrophages (2.18E-04), Thyroid Cancer (4.75E-04), Amyloidosis (5.47E-04) |
23 | Proliferation Of BMMC Cells (3.00E-05), Cough (4.94E-05), Proliferation Of Blood-Derived Mast Cells (6.79E-05), Whooping Cough (6.79E-05), Development Of Neuroglia (1.71E-04), Acute Otitis Media (2.03E-04) |
24 | Abnormal Morphology Of Mossy Fibers (3.15E-04), Tonic Seizure (6.34E-04), Function Of CD4+ T-Lymphocytes (6.53E-04), Rheumatic Disease (7.12E-04), Quantity Of Methotrexate (7.94E-04), Morphogenesis Of Embryonic Organ (9.32E-04) |
25 | Damage Of Septal Neurons (7.97E-05), Development Of Tectorial Membrane (7.97E-05), Proliferation Of Stromal Cell Lines (7.97E-05), Imprinting (1.61E-04), Congenital Anomaly Of Mouth (1.93E-04), Growth Of Otic Vesicle (2.38E-04) |
26 | Adenocarcinoma (8.24E-05), Renal-Cell Carcinoma (9.62E-05), Efflux Of Halide (2.26E-04), Efflux Of Monovalent Inorganic Anion (2.26E-04), Development Of Cecum (3.20E-04), Morphology Of Jaw (3.69E-04) |
27 | Chemotaxis Of Helper T Lymphocytes (1.46E-04), Abnormal Morphology Of Body Cavity (2.60E-04), Cell Movement Of Helper T Lymphocytes (3.59E-04), Proliferation Of Gamma-Delta T Lymphocytes (4.36E-04), Accumulation Of Very Long Chain Fatty Acid (4.72E-04), Sick Sinus Syndrome (4.72E-04) |
28 | Papillary Thyroid Cancer (1.91E-05), Autosomal Recessive Deafness (2.53E-04), Contraction Of Striated Muscle (2.76E-04), Autosomal Recessive Nonsyndromic Hearing Loss (3.39E-04), Thyroid Cancer (4.28E-04), Sick Sinus Syndrome (7.04E-04) |
29 | Fate Determination Of Cells (4.32E-04), Extension Of Axons (6.97E-04), Delay In Puberty (1.14E-03), Olfactory Response Of Organism (1.33E-03), Spondylarthritis (1.44E-03), Cytotoxicity Of Lymphocytes (1.57E-03) |
30 | Generation Of Plasma Cells (3.44E-04), Quantity Of Follicular T Helper Cells (3.44E-04), Activation Of Purkinje Cells (3.15E-03), Autosomal Recessive GLUT1 Deficiency Syndrome Type 1 (3.15E-03), Biogenesis Of Lateral Plasma Membrane (3.15E-03), Clustering Of Clathrin-Coated Pits (3.15E-03) |
31 | Bleeding Of Kidney (5.10E-04), Chronic Large Plaque Psoriasis (1.27E-03), Chronic Small Plaque Psoriasis (1.27E-03), Induction Of Helper T Lymphocytes (1.47E-03), Swelling Of Ear (1.47E-03), Birthweight (1.64E-03) |
32 | Diameter Of Blood Vessel (9.72E-04), Morphology Of Lung (1.16E-03), Alveologenesis Of Lung (2.19E-03), Abnormal Morphology Of Lung (2.26E-03), Antley-Bixler Syndrome Without Genital Anomalies Or Disordered Steroidogenesis (2.33E-03), Beare-Stevenson Cutis Gyrata Syndrome (2.33E-03) |
SAHA | Migration Of Tumor Cells (2.27E-08), Colorectal Cancer (5.80E-08), Gastrointestinal Tract Cancer (4.79E-07), Cell Movement Of Tumor Cells (7.70E-07), Cell Movement Of Cancer Cells (6.34E-06), Neoplasia Of Colon (1.75E-05) |
