Figure 1 | Scientific Reports

Figure 1

From: The complex and specific pMHC interactions with diverse HIV-1 TCR clonotypes reveal a structural basis for alterations in CTL function

Figure 1

Differential antiviral efficacy of B*27-KK10 specific clonotypes.

(A). The ability of KK10-specific clonotypes to recognize NL4-3 wild-type and variant viruses was tested in the standard 4-h chromium release assay with virally infected HLA-B*2705-encoding green fluorescent protein (GFP) reporter GXR cells at an effector/target cell ratio of 1:1. Viable infected (GFP-positive) GXR cells were sorted by a FACS Aria cell-sorting instrument after infection for 5 days and used as target cells. (B). The FEP simulation results for the predicted TCR-KK10 binding free energy change due to L6M and R2T single mutations and R2TL6M double mutation in viral peptide KK10.

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