Figure 1 | Scientific Reports

Figure 1

From: RETRACTED ARTICLE:Type IV collagen α1-chain noncollagenous domain blocks MMP-2 activation both in-vitro and in-vivo

Figure 1

α1(IV)NC1 inhibits cellular invasion.

(a and b) Invasion in HUVECs treated with VEGF or APMA alone or combination with α1(IV)NC1. α1(IV)NC1 treated cells was shown in black bars and absence of VEGF or APMA was shown in white bars. *IndicatesP < 0.03; α1(IV)NC1 treatment compared to VEGF or APMA treatment alone. (c) VEGF-induced invasion by TIMP-2 and α1(IV)NC1. **Indicates P < 0.04 (VEGF against α1(IV)NC1); *indicates P < 0.05 (VEGF against TIMP-2); ***indicates P < 0.03 (VEGF against TIMP-2/α1(IV)NC1). (d) SCC-PSA-1 teratocarcinoma cell invasion. *Indicates P < 0.05 control against α1(IV)NC1.

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