Figure 2

Regulation of MMP-2 activation by α1(IV)NC1.
(a and b) MMP-9, MMP-2 and MMP-7 activity in gelatin and casein zymography of conditioned wild type and α1-integrin null mouse lung endothelial cell (MLEC) culture medium. Lane 1 and 2, without and with α1(IV)NC1 treatment in wild type MLEC medium. Lane 3 and 4, without and with α1(IV)NC1 treatment in α1-integrin null MLEC medium.