Figure 6
Regulation of tumor angiogenesis by α1(IV)NC1 in mice.
(a) Tumor growth in wild type and α1-integrin null mice. Results shown are mean ± SEM. p < 0.005 compared with α1-integrin null tumor mice with higher dose and without α1(IV)NC1 treatment. (b and c) The tumors and average tumor weights of different groups were showed in panel (a). The average tumors volume and weights were shown mean ± SEM. p < 0.005 compared with α1-integrin null mice tumor with higher dose and without α1(IV)NC1 treatment. (d) Number of CD31 positive blood vessels in different tumors of panel (a) (arrow) were quantified in 6 fields at 200X magnification. Scale bar corresponds to 50-μm. *indicates, p < 0.005; compared to α1-integrin null mice with low and high dose. **indicates, p < 0.001; compared to wild type mice with and without treatment.
