Table 1 Regulation of MMP-2 activation by α1(IV)NC1

From: RETRACTED ARTICLE:Type IV collagen α1-chain noncollagenous domain blocks MMP-2 activation both in-vitro and in-vivo

Angiogenesis inhibitor name

Human α1(IV)NC1

Inhibitor origin

α1-chain type IV collagen NC1 domain

Generation of inhibitor

By MMP-9

MMP-2 activation

Effects

MMP-9 activation

No effect

TIMP-2 and MT1-MMP

Regulation

Signaling

α1β1 integrin mediated endothelial specific signaling

Regulation of MMP-2 activation

By forming stable complex with MMP-2

Back to article page