Figure 4
From: Functional transformations of bile acid transporters induced by high-affinity macromolecules
LHe-tetraD stimulates ASBT internalization in vesicles.
The vesicular transport of ASBT (a–e) as illustrated by the schematic representation (f) was observed by TEM. ASBT was detected (arrow) in the membrane of MDCK-ASBT cells as gold-marks (a). Following the LHe-tetraD treatment, the gold-marks appeared in distinctively concave-shaped membrane curvatures (b), in vesicles near the membrane (c) and in the multi-vesicular bodies (asterisks) in the cytoplasm (d and e). Scale bar indicates 200 nm.
