Figure 7
From: Functional transformations of bile acid transporters induced by high-affinity macromolecules
The schematic of the new model for the ASBT transport mechanism.
In the conventional transport mechanism, ASBT moves only small molecule substrates into the cytoplasm through its transmembrane domain. In the newly proposed vesicular transport mechanism, the transformation of ASBT can be induced by high-affinity binding macromolecular substrates that lend the transporter to carry its substrates to the cytoplasm in vesicles.
