Figure 5
From: Interferon β protects against lethal endotoxic and septic shock through SIRT1 upregulation
SIRT1-expressing adenovirus infection and IFN-β treatment attenuate organ injury induced by LPS.
Morphological changes in mouse kidney (A) and spleen (B) sections infected with LacZ- or SIRT1-expressing adenovirus for 48 h, or treated with vehicle or IFN-β for 30 min before LPS challenge (magnification, ×40). Organ sections were obtained from mice 15 h after treatment with LPS at 18 mg/kg body weight, perfused and fixed with formalin and stained with hematoxylin and eosin.
