Figure 4
From: Heterogeneity of Li-Fraumeni Syndrome links to unequal gain-of-function effects of p53 mutations
Multivariate analysis on the effects of each p53 mutation on cancer onset.
(a) The potential effects of p53 mutation, cancer type and patient sex on the age of cancer onset were analyzed by forward conditional COX regression model. The variables in the model include cancer types and mutations of p53. Tumors in several tissue types (including bone, brain, breast, lung and stomach) showed higher hazard ratios (HRs) than in adrenal gland, which was set as a reference condition. As for the germline allele status of TP53 gene, the nonsense and G245 mutations showed significantly later onset than the mutation on R248 (reference condition). Other hotspot mutations (including R175, R273, R282 and Y220) showed no significant difference in the age of cancer onset (P > 0.05). (b) Plot of hazard ratio and 95% confidence interval for each factor in the COX regression model.
