Figure 3

STAT3 activation by KSHV alters DC cytokine release.
ELISA assay to measure the IL-10, IL-6 and IL-23 release by DCs or IL-12p70 release by LPS-treated DCs, exposed to (A) active or (B) UV-KSHV. Histograms (mean ± SD of three independent experiments) represent the amount of cytokines produced by mock and KSHV-exposed DCs, in the presence or in the absence of STAT3 inhibitor AG490 (50 μg/ml).