Figure 1
From: CEBPA-dependent HK3 and KLF5 expression in primary AML and during AML differentiation
HK3 and KLF5 expression is significantly downregulated in CEBPA-mutated AML patients.
HK3 (a) and KLF5 (b) mRNA levels were measured by qPCR in total RNA extracted from primary AML (FAB M0-M7) blasts, CD34+ samples or granulocytes from healthy donors. Patient characteristics are summarized in Supplementary Table 1. HK3 (c) and KLF5 (d) levels in 154 patients from the Taskesen cohort with normal karyotype, expressing wild type CEBPA (WT), one allele mutated (SM) or two alleles mutated (DM). MWU: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
