Figure 8
From: Microglia trigger astrocyte-mediated neuroprotection via purinergic gliotransmission
Schematic diagram illustrating the communication pathways among microglia, astrocytes and neurons responsible for neuroprotection.
When exposed to MeHglow, microglia sense MeHglow and activation of p38 MAPK occurs. This is followed by VNUT-dependent ATP exocytosis. The microglia-derived ATP in turn activates P2Y1 receptors and induces Ca2+ oscillations in astrocytes. The activation of P2Y1 receptors induces IL-6 release from astrocytes, thereby leading to neuroprotection against MeHg.
