Figure 8 | Scientific Reports

Figure 8

From: Nitric Oxide Inhibits Hetero-adhesion of Cancer Cells to Endothelial Cells: Restraining Circulating Tumor Cells from Initiating Metastatic Cascade

Figure 8

Mechanisms of action by which CAP-NO inhibits adhesion of CTCs to vascular endothelium.

CAP-NO makes direct vasorelaxation, increases blood flow, inhibits platelet activation and aggregation. As a result, CAP-NO interfered with the hetero-adhesion between CTCs and vascular endothelial cells by down-regulation of CAMs expression induced by cytokines. A series of beneficial effects of CAP-NO in preventing CTCs from adhesion, invasion to endothelial bed and the resultant micrometastatic foci may attribute to its collective actions.

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