Figure 1
From: Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation
Structural model of full-length talin.
(a) Talin is comprised of a FERM domain containing Head joined by a large unstructured linker to a flexible rod comprised of thirteen 4- or 5- helix bundles (R1–R13). The talin rod has two distinct regions, a compact N-terminal region (R1–R3) and a linear C-terminal region (R4–R13). Putative vinculin binding sites are shown in blue. (Inset) Schematic representation of the compact region of the talin rod studied in this work. The threonine belt that destabilizes the R3 domain is highlighted. (b) Schematic of three possible force-dependent conformations of a talin rod domain.
