Figure 2 | Scientific Reports

Figure 2

From: Dihydromyricetin promotes hepatocellular carcinoma regression via a p53 activation-dependent mechanism

Figure 2

DHM regulates survival signals and activates the apoptosis-related signaling pathway.

(A) The expression of apoptosis-related proteins in HepG2 cells after DHM treatment. (B) The expression of apoptosis-related proteins in HL7702 cells after DHM treatment (12 h DHM treatment). (C) Activated caspase proteins (cleaved caspases) were quantified by optical density analysis. (D) AKT and p-AKT proteins were reduced in HepG2 cells after DHM stimulation (12 h treatment). (E) AKT and p-AKT proteins were downregulated in SMMC-7721 but not affected in HL7702 cells after DHM stimulation. (F, G) p-AKT and AKT proteins were quantified by optical analysis in HepG2, SMMC-7721 and HL7702 cells.

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