Table 1 EC₅₀s of compounds against tested Trypanosoma cruzi strains and clones

	Dm28c	Y	ARMA13 cl1	ERA cl2	92-80 cl2	CL Brener	Tulahuen
	DTU I	DTU II	DTU III	DTU IV	DTU V	DTU VI	DTU VI
Benznidazole	2.5 × 10⁻⁶	2.4 × 10⁻⁶	7.3 × 10⁻⁷	1.1 × 10⁻⁶	7.0 × 10⁻⁷	1.6 × 10⁻⁶	6.3 × 10⁻⁷
Nifurtimox	1.5 × 10⁻⁶	1.4 × 10⁻⁶	1.9 × 10⁻⁷	2.3 × 10⁻⁷	1.9 × 10⁻⁷	3.5 × 10⁻⁷	2.4 × 10⁻⁷
Fexi. Sulfone	7.5 × 10⁻⁶	1.1 × 10⁻⁵	1.9 × 10⁻⁶	2.4 × 10⁻⁶	1.4 × 10⁻⁶	1.3 × 10⁻⁶	3.0 × 10⁻⁶
AN4169	3.7 × 10⁻⁷	4.4 × 10⁻⁷	2.1 × 10⁻⁷	2.8 × 10⁻⁷	1.5 × 10⁻⁷	1.9 × 10⁻⁷	2.8 × 10⁻⁷
Posaconazole	5.3 × 10⁻⁹	1.1 × 10⁻⁸	-	9.1 × 10⁻⁹	-	1.2 × 10⁻⁹	1.0 × 10⁻⁹
Ravuconazole	3.6 × 10⁻⁹	1.1 × 10⁻⁹	8.7 × 10⁻¹⁰	2.2 × 10⁻⁹	-	7.4 × 10⁻¹⁰	6.2 × 10⁻¹⁰
EPL-BS967	2.2 × 10⁻⁸	1.8 × 10⁻⁷	-	8.2 × 10⁻⁹	1.0 × 10⁻⁷	-	5.2 × 10⁻⁸
EPL-BS1246	2.7 × 10⁻⁷	6.1 × 10⁻⁸	-	1.4 × 10⁻⁷	6.1 × 10⁻⁷	2.1 × 10⁻⁸	1.9 × 10⁻⁸

All values refer to compound molarity (M); in cases denoted by “-”, the maximum activity of the compound was below 50% at the highest concentration tested and thus EC₅₀s could not be determined; see also Table 2. Data obtained from at least two independent experiments.

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