Table 3 Efficacious compound concentrations and average normalized infection ratio (%) at 72-, 96- and 144-h of continuous compound exposure

From: Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development

Compound

Concentration

Av. Norm. Inf. Ratio (%)

  

72 h

96 h

144 h

Benznidazole

2.0 × 10−4 M

−1.4

±3.1

0.2

±3.1

-

-

 

1.0 × 10−4 M

0.8

±5.1

0.8

±3.0

-

-

Nifurtimox

5.0 × 10−5 M

−1.5

±3.5

−1.0

±1.4

-

-

 

2.5 × 10−5 M

0.5

±2.1

−1.0

±1.4

-

-

 

1.25 × 10−5 M

0.5

±0.7

0.0

±1.4

-

-

Fexi. Sulfone

2.0 × 10−4 M

0.0

±5.6

−0.5

±2.1

-

-

 

1.0 × 10−4 M

0.0

±4.2

1.5

±0.7

-

-

AN4169

5.0 × 10−6 M

9.0

±4.2

4.5

±0.7

-

-

 

2.5 × 10−6 M

9.5

±3.5

4.0

±2.8

-

-

Posaconazole

8.0 × 10−8 M

35.0

±7.9

19.3

±13.2

7.0

±6.0

 

4.0 × 10−8 M

38.3

±15.0

33.0

±34.8

7.0

±6.6

Ravuconazole

8.0 × 10−8 M

32.7

±10.0

15.0

±10.5

4.7

±5.1

 

4.0 × 10−8 M

28.3

±8.7

12.3

±7.6

3.7

±4.1

EPL-BS967

2.0 × 10−6 M

18.0

±7.0

8.3

±6.5

4.7

±5.5

 

1.0 × 10−6 M

19.3

±9.0

10.0

±7.2

5.0

±4.0

EPL-BS1246

2.0 × 10−6 M

22.3

±10.1

9.7

±6.5

3.7

±4.0

 

1.0 × 10−6 M

24.7

±7.2

10.3

±6.4

4.7

±3.2

  1. Data refer to means and standard deviations obtained from at least two independent experiments.
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