Figure 4
Intravital bioluminescence imaging of Δp230p-GFP-LUC and Δslarp-GFP-LUC P. berghei liver stage infection.
(A–C). C57BL/6 mice were injected intravenously with 50,000 sporozoites of control Δp230p-GFP-LUC (left panels) or mutant Δslarp-GFP-LUC (right panels) and imaged at 24, 48 and 96 hours post-infection after intraperitoneal injection of D-luciferin. (E–F). Quantification of luminescence levels in the whole body of mice infected with Δp230p-GFP-LUC (grey bars) or mutant Δslarp-GFP-LUC (black bars). Data are expressed as photons/second (mean +/− sd, **p < 0.01, Mann-Whitney test). Dotted red lines represent baseline measurement of naive mice.
