Figure 1 | Scientific Reports

Figure 1

From: Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA

Figure 1

Hepatitis C NS5A and inhibitor structures.

Chemical structures of (a) BMS-790052 and (b) AZD7295. (c) NS5A domain structure. SP denotes the signal peptide and AH is an N-terminal amphipathic helix. (d) Proposed mechanism of action of NS5A inhibition. Compound binding to NS5A domain 1 prevents RNA binding. Models of observed NS5A1–191 dimer conformations (based on crystal structures PDB ID: 1ZH110 and 3FQQ11 and the NMR structure PDB ID: 1R7G19) displayed as cartoon and coloured by monomer. The location of Y93 in each monomer is indicated by red cpk and the Zn2+ ions are orange spheres.

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