Figure 5
From: Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA
Binding to domain 1 NS5A26–202 L31V genotype 1b (con1).
Binding of (a) 4rU, (b) 5rU, (c) 10rU, (d) 5rA, (e) BMS-790052 or (f) AZD7295 to NS5A26–202 L31V. Values on the Y-axis represent the percentage of the maximal thermophoretic response observed, or in the case of no detectable binding values on the Y-axis represent the thermophoretic shift of the labelled protein. All binding curves were determined in triplicate by MST and are represented as the mean ± SD.
