Figure 6
From: Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA
SEC-MALLS analysis of domain 1 NS5A33–202 genotype 1b (con1) oligomerisation state.
(a) Solution molecular weight analysis of NS5A33–202 domain 1. (b) Molecular weight analysis in the presence of 5rU, (c) BMS-790052, (d) AZD7295. All molecular weights were determined by MALLS and are shown as grey points, with the black trace representing the absorbance at 280 nm recorded by an AKTApurifier.
