Table 3 Stratification analyses between MDM2 SNP309 genotypes and CRC risk

From: MDM2 SNP309 polymorphism is associated with colorectal cancer risk

  

Genotypes (cases/controls)

  
 

Cases/controls

TT

TG/GG

  

Variables

N

N

%

N

%

TG/GG vs. TT Adjusted OR (95% CI)a

P a

Age (years)

       

≤60

277/348

57/82

20.6/23.6

220/266

79.4/76.4

1.15 (0.78–1.70)

0.468

> 60

296/240

54/68

18.2/28.3

242/172

81.8/71.7

1.76 (1.17–2.64)

0.007

Sex

       

Male

354/367

64/93

18.1/25.3

290/274

81.9/74.7

1.52 (1.06–2.19)

0.023

Female

219/221

47/57

21.5/25.8

172/164

78.5/74.2

1.28 (0.82–2.01)

0.274

Smoking status

       

No

377/408

85/109

22.6/26.7

292/299

77.5/73.3

1.28 (0.92–1.79)

0.141

Yes

196/180

26/41

13.3/22.8

170/139

86.7/77.2

1.90 (1.11–3.27)

0.020

Drinking status

       

No

414/451

82/118

19.8/26.2

332/333

80.2/73.8

1.42 (1.03–1.96)

0.035

Yes

159/137

29/32

18.2/23.4

130/105

81.8/76.6

1.44 (0.81–2.55)

0.218

Family history of cancer

       

 No

443/546

93/141

21.0/25.8

350/405

79.0/74.2

1.33 (0.98–1.80)

0.063

 Yes

130/42

18/9

13.9/21.4

112/33

86.1/78.6

1.31 (0.51–3.37)

0.578

  1. aOR (odds ratio), CI (confidence interval) and P values were calculated in dominant model with adjustment for age, sex, smoking status and alcohol use.
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