Table 2 Results of association analysis for HLA types and CM-SJS/TEN with SOC in Group 1 (KPUM)

From: Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement

HLA genotype

Carrier frequency (%)

Dominant model analysis

 

Case (n = 131)

Control (n = 419)

P

Pc

Odds ratio (95% CI)

HLA-A

     

A*02:06

62/131 (47.3%)

57/419 (13.60%)

2.79.E-16

4.75E-15

5.71 (3.666-8.881)

A*03:01

5/131 (3.82%)

4/419 (0.95%)

0.0242

0.412

4.12 (1.089-15.564)

A*11:01

10/131 (7.6%)

71/419 (16.95%)

8.67.E-03

0.147

0.405 (0.202-0.811)

A*24:02

57/131 (43.5%)

256/419 (61.10%)

3.89.E-04

6.60.E-03

0.490 (0.330-0.730)

HLA-B

     

B*13:01

10/131 (7.6%)

13/419 (3.10%)

0.0237

0.807

2.58 (1.104-6.032)

B*15:01

11/131 (8.4%)

69/419 (16.47%)

0.0222

0.755

0.465 (0.238-0.908)

B*44:02

5/131 (3.82%)

5/419 (1.19%)

0.0498

1.69

3.29 (0.936-11.532)

B*44:03

31/131 (23.7%)

66/419 (15.75%)

0.0381

1.29

1.66 (1.024-2.682)

B*46:01

22/131 (16.8%)

38/419 (9.07%)

0.0133

0.453

2.02 (1.148-3.566)

B*52:01

12/131 (9.2%)

79/419 (18.85%)

9.16.E-03

0.311

0.434 (0.228-0.825)

B*54:01

10/131 (7.6%)

61/419 (14.56%)

0.0391

1.33

0.485 (0.241-0.976)

HLA-C

     

C*03:04

42/131 (32.1%)

98/419 (23.39%)

0.0467

0.841

1.55 (1.00-2.38)

C*05:01

5/131 (3.82%)

5/419 (1.19%)

0.0498

0.897

3.29 (0.936-11.532)

C*12:02

13/131 (9.9%)

80/419 (19.09%)

0.0145

0.262

0.467 (0.251-0.870)

  1. P: P values obtained with χ2-tests.
  2. Pc: P values corrected for the multiplicity of testing by the number of comparisons (17, 34 and 18 for HLA-A, HLA-B and HLA-C, respectively).
  3. CM-SJS/TEN: cold medicine related SJS/TEN who had taken cold medicine.
  4. SOC: severe ocular surface complications.
  5. CI: confidence interval.
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