Table 3 Results of association analysis between HLA types and CM-SJS/TEN with SOC in Group 2 (NIHS)

From: Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement

 

Carrier frequency (%)

Dominant model analysis

HLA genotype

Case (n = 20)

Control (n = 220)

P

Pc

Odds ratio (95% CI)

HLA-A

     

A*02:06

9/20 (45.0%)

30/220 (13.6%)

0.0014

0.00560

5.18 (1.98–13.56)

A*03:01

0/20 (0%)

19/220 (8.6%)

0.3804

  

A*11:01

2/20 (10.0%)

39/220 (17.7%)

0.5408

  

A*24:02

14/20 (70.0%)

132/220 (60.0%)

0.4770

  

HLA-B

     

B*13:01

2/20 (10%)

6/220 (2.7%)

0.1364

  

B*15:01

2/20 (10%)

39/220 (17.7%)

0.5408

  

B*44:02

0/20 (0%)

4/220 (1.8%)

1.0000

  

B*44:03

8/20 (40.0%)

30/220 (13.6%)

0.0058

0.0406

4.22 (1.59–11.19)

B*46:01

2/20 (10%)

18/220 (8.2%)

0.6764

  

B*52:01

1/20 (5.0%)

48/220 (21.8%)

0.0857

  

B*54:01

5/20 (25%)

33/220 (15.0%)

0.3316

  

HLA-C

     

C*03:04

6/20 (30%)

43/220 (19.5%)

0.2573

  

C*05:01

0/20 (0%)

4/220 (1.8%)

1.0000

  

C*12:02

1/20 (5.0%)

47/220 (21.4%)

0.1388

  
  1. P: p-values obtained by Fisher's exact tests are shown.
  2. Pc: p-values corrected for the mutiplicity of testing by the number of comparisons: (4, 7 and 3 for HLA-A, HLA-B and HLA-C, respectively).
  3. CM-SJS/TEN: cold medicine related SJS/TEN who had taken cold medicine.
  4. SOC: severe ocular surface complications.
  5. CI: Confidence interval.
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