Figure 1 | Scientific Reports

Figure 1

From: Nitro-oleic acid downregulates lipoprotein-associated phospholipase A2 expression via the p42/p44 MAPK and NFκB pathways

Figure 1

OA-NO2 downregulates Lp-PLA2 expression.

THP-1 cells were incubated with OA-NO2 and OA at the indicated concentrations for 1 h and then stimulated with PMA (0.05 μM). (A), The relative Lp-PLA2 mRNA expression levels were determined after stimulation with PMA for 12 h. (B), The Lp-PLA2 protein expression levels were determined after stimulation with PMA for 24 h. (C), The relative Lp-PLA2 mRNA expression levels were determined after stimulation with PMA for 4 h, 12 h and 24 h. (D), Peripheral blood mononuclear cells isolated from ApoC III TG pigs were incubated with OA-NO2 at the indicated concentrations for 12 h and the relative Lp-PLA2 mRNA expression levels were then determined. All data are presented as the mean ± SEM (n = 3); *P < 0.05, **P < 0.005 compared with PMA treatment based on analysis of variance.

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