Figure 3 | Scientific Reports

Figure 3

From: Nitro-oleic acid downregulates lipoprotein-associated phospholipase A2 expression via the p42/p44 MAPK and NFκB pathways

Figure 3

The OA-NO2-induced downregulation of lp-PLA2 occurs via a PPARγ-independent mechanism.

THP-1 cells were incubated with OA-NO2, Rosiglitazone and GW9662 at the indicated concentrations for 1 h and then stimulated with PMA (0.05 μM). (A and C), The relative Lp-PLA2 mRNA expression levels were determined after stimulation with PMA for 12 h. (B), The activation of PPARγ and Lp-PLA2 protein expression levels were determined after stimulation with PMA for 24 h.

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