Figure 4
From: Design principles of stripe-forming motifs: the role of positive feedback
Changes in the functional parameter space produced by adding positive feedbacks to the IFFMs.
The positive feedbacks added to the IFFMS are: two self-activations (of gene B and C) and the B-C interaction. We show thus three graphs associated to these three added positive feedbacks. The graphs illustrate the change in the extent of the functional parameter space as the positive feedback increases. More precisely, they include the fraction of the functional parameter space of the RIFFMs, each scaled to the extension of the functional parameter space of a lower level RIFFM. This comparison methodology is illustrated in the lower panels for the mutual-inhibition and the mutual-activation of the 4-link networks. In these two examples, the parameter space to be compared is (ωAB, ωAC, ωCB) with (absolute) values ωXY ∈ [0, 10] (Gray cube). The functional region of parameter space is represented by the red shape. The behaviour illustrated in these three graphs is generic for the addition of each of the three types of positive feedback, independent of the existing positive feedbacks in the network. We wish to point out the parametric boost brought by the mutual-inhibition in the I1 branch and the complete neutrality introduced by the mutual-activation and stripe-gene self-activation in the I3 branch.
