Figure 2 | Scientific Reports

Figure 2

From: Synergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis

Figure 2

Structure and pharmacological effects of UA-4.

a, the structural formula of UA-4; b, dose-response of anti-proliferative effect of UA-4 on A-375, HepG2 and HELF cells; c, effects of UA-4 on cell cycle distribution in A-375 cells; d, effects of UA-4 on ΔΨm in A-375 cells. Results are expressed as percentage change in UA-4 treatment compared to the vehicle-treated control (*P < 0.05, **P < 0.01). e, A-375 cells were treated with UA-4 (1, 5, 10 μM) for 12 h and 24 h (f), respectively. Apoptosis was determined by Annxin-V-FITC/PI labeling. g, One step TUNEL apoptosis was tested on A-375 cells treated with UA-4 (1, 5, 10 μM) for 24 h.

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