Table 1 In vitro activity of UA, its derivatives UA-1 ~ UA-9 and paclitaxel on human tumor cells vs. normal cell lines

From: Synergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis

 

IC50 (μM)a

Compound

HepG2

AGS

A-375

HeLa

HELF

UA

68.82 ± 3.71

43.25 ± 2.13

57.55 ± 3.21

33.12 ± 0.63

21.28 ± 1.76

UA-1

71.26 ± 2.18

42.88 ± 1.22

50.89 ± 1.79

26.09 ± 1.99

54.53 ± 2.01**

UA-2

16.32 ± 1.76**

14.51 ± 0.85**

4.15 ± 0.98**

4.37 ± 2.51**

18.08 ± 2.05

UA-3

15.97 ± 2.18**

14.07 ± 1.37**

4.07 ± 1.22**

4.19 ± 2.86**

25.11 ± 2.86

UA-4

7.20 ± 2.04**

12.84 ± 2.15**

3.86 ± 1.52**

3.79 ± 3.14**

14.9 ± 2.81*

UA-5

17.34 ± 2.53**

—b

5.06 ± 1.26**

8.56 ± 0.12*

36.05 ± 1.82**

UA-6

13.9 ± 0.78**

17.72 ± 2.31**

13.63 ± 2.39**

14.56 ± 1.12**

15.43 ± 2.37

UA-7

14.44 ± 1.38**

17.48 ± 1.64**

15.07 ± 1.47**

14.45 ± 2.65**

15.01 ± 1.89

UA-8

13.42 ± 2.31**

16.56 ± 1.80**

11.9 ± 1.33**

13.27 ± 0.87**

12.37 ± 0.69*

UA-9

26.65 ± 1.403*

—b

16.40 ± 0.87**

16.90 ± 1.69*

39.40 ± 1.43

Paclitaxel

10.32 ± 0.02**

9.24 ± 0.13**

8.56 ± 0.07**

6.62 ± 0.21**

7.17 ± 0.08*

  1. aDrug concentration that inhibits cell growth by 50%.
  2. bNo data were recorded by “—”.
  3. Data represents mean ± SD (n = 6).
  4. *P < 0.05;
  5. **P < 0.01 compared to the vehicle-treated control.
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