Figure 5
From: Interleukin-37 Mediates the Antitumor Activity in Hepatocellular Carcinoma: Role for CD57+ NK Cells
Overexpression of IL-37 delayed tumor growth and enhanced local CD57+ NK cells infiltration within murine tumors.
(A) Stable IL-37 expression in Hepa1-6 cells was confirmed by western blotting. The cropped blots were shown. (B) The tumor growth curves of IL-37 overexpression group (Hepa 1-6/LV-IL37) and control group (Hepa 1-6/LV-NC) were compared. * p < 0.05 versus control. (C) Photographs of dissected tumors from the C57BL/6 mice of IL-37 overexpression group and control group. (D) Dissected tumor weights from IL-37 overexpression group and control group were compared. (E) Representative photomicrographs showing immunohistochemical staining of IL-37, CD57, CD3 and CD8 in murine tumors. (F) The density of CD57+ NK cells, CD3+ or CD8+ T cell infiltration in IL-37 overexpression group and control group was compared. The values shown are expressed as the mean ± SD. The p values were calculated using Student's t-test.
