Table 1 Association between individual SNP and KD risk

From: The Roles of Ca2+/NFAT Signaling Genes in Kawasaki Disease: Single- and Multiple-Risk Genetic Variants

    

W/H/V frequency

    

Chr

Gene

rs ID

MAF in CHB*

KD cases

Controls

Reference/Variant allele

OR†

95% CI

LR P‡

4

         
 

CASP3

rs2720378

0.326

184/186/56

253/191/49

G/C

1.39 §

1.07–1.80

0.014

 

IL-2

rs2069762

0.239

170/193/55

230/210/52

A/C

1.28§

0.98–1.67

0.066

 

STIM2

rs10263

0.367

174/196/53

207/220/65

A/G

0.94

0.64–1.39

0.760

11

         
 

STIM1

rs1561876

0.344

244/151/23

266/193/32

A/G

0.84§

0.65–1.10

0.204

 

STIM1

rs3750994

0.244

298/112/16

334/137/20

T/G

0.91§

0.69–1.21

0.529

 

STIM1

rs3750996

0.133

249/142/19

287/172/25

A/G

0.94§

0.72–1.23

0.663

18

         
 

NFATc1

rs9966033

0.378

158/209/53

184/222/74

T/C

0.79

0.54–1.16

0.230

 

NFATc1

rs754093

0.311

176/197/45

222/206/63

T/G

0.82

0.55–1.23

0.338

 

NFATc1

rs7227107

0.367

167/201/54

194/224/68

A/G

0.90

0.62–1.33

0.600

19

         
 

ITPKC

rs28493229

0.070∥

359/63/4

422/71/0

G/C

1.11§

0.77–1.59

0.573

 

ITPKC

rs10420685

0.178

230/158/38

267/184/40

A/G

1.10

0.69–1.76

0.675

 

ITPKC

rs2290692

0.433

109/190/112

111/238/119

G/C

0.86§

0.64–1.17

0.344

 

ITPKC

rs2561530

0.270∥

230/160/33

258/202/28

A/G

1.39

0.83–2.34

0.215

 

ITPKC

rs4802085

0.500

129/187/103

129/238/102

G/C

1.17

0.86–1.60

0.317

20

         
 

NFATc2

rs6013193

0.330

150/210/67

157/251/84

T/G

0.87§

0.66–1.14

0.302

  1. Abbreviations: MAF, minor allele frequency; CHB, Han Chinese in Beijing; Chr, chromosome; W, wild type homozygote; H, heterozygote; V, variant homozygote; OR, odds ratio; 95%CI, 95% confidence interval; LR, logistic regression
  2. *MAF was downloaded from the online database of HapMap for Han Chinese in Beijing, China
  3. †OR calculation was conducted under assumption that variant alleles were risk alleles
  4. ‡All the P values were adjusted for gender. The positive results were in bold
  5. §The inheritance model of the risk alleles was dominant
  6. The inheritance model of the risk alleles was recessive
  7. ∥MAF was downloaded from the online database of 1000 Genomes for Han Chinese in Beijing, China
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