Figure 4
Hierarchical clustering and profiles of the 53 hits.
(A) Hierarchical clustering of the 3 parameters for the 53 hits. Compounds were considered as hits when inducing a change superior to DMSO ± 2σDMSO and when deviating from normal distribution (see methods section). Heatmap represents intensities of normalized ratios. (B–D) Remarkable profiles, i.e. combinations of the scores in each of the assays. (B) Profiles of toxic compounds that reduce significantly the three parameters. (C) Profiles of the cluster of compounds that increase significantly redox potential only. (D) Profiles of the cluster of compounds that increase significantly Δψm only.
