Table 2 Meta-analysis Results

From: The -1082A>G polymorphism in promoter region of interleukin-10 and risk of digestive cancer: a meta-analysis

 

G vs. A

GG vs. AA

GA vs. AA

GGGA vs. AA

 

Studies

OR (95% CI)

Pheter

Studies

OR (95% CI)

Pheter

Studies

OR (95% CI)

Pheter

Studies

OR (95% CI)

Pheter

Overall

37

1.181 (1.057–1.319)*

<0.001

33

1.305 (1.044–1.631) *

<0.001

37

1.168 (1.015–1.344) *

<0.001

40

1.153 (1.005–1.323) *

<0.001

Cancer Types

            

CRC

4

0.937 (0.805–1.090)

0.71

4

0.873 (0.638–1.195)

0.737

4

0.914 (0.709–1.179)

0.572

4

0.903 (0.709–1.149)

0.552

EC

3

0.982 (0.820–1.175)

0.591

3

0.872 (0.559–1.361)

0.864

3

1.113 (0.850–1.456)

0.761

3

1.070 (0.825–1.387)

0.656

GC

25

1.281 (1.102–1.488) *

<0.001

22

1.575 (1.146–2.164) *

<0.001

25

1.277 (1.067–1.527) *

<0.001

26

1.275 (1.056–1.538) *

<0.001

HCC

4

1.104 (0.797–1.530)

0.283

3

1.355 (0.587–3.124)

0.757

4

1.022 (0.714–1.463)

0.335

6

0.912 (0.739–1.126)

0.431

Ethnicity

            

Asian

22

1.399 (1.188–1.646) *

<0.001

19

2.072 (1.446–2.971) *

0.068

22

1.397 (1.161–1.680) *

<0.001

24

1.351 (1.108–1.649) *

<0.001

Caucasian

10

1.016 (0.930–1.111)

0.796

10

1.055 (0.880–1.264)

0.649

10

0.973 (0.786–1.205)

0.044

11

1.010 (0.881–1.159)

0.386

Control Source

            

PB

16

1.151 (1.001–1.324) *

<0.001

15

1.336 (0.973–1.835)

<0.001

16

1.118 (0.915–1.364)

0.001

17

1.153 (0.964–1.379)

0.001

HB

21

1.212 (1.014–1.449) *

<0.001

18

1.246 (0.940–1.650)

0.38

21

1.216 (0.992–1.489)

<0.001

23

1.153 (0.935–1.422)

<0.001

Sample Size

            

Small

22

1.151 (1.010–1.312) *

0.016

18

1.291 (1.010–1.649) *

0.191

22

1.170 (0.973–1.406)

0.026

25

1.109 (0.927–1.327)

0.001

Large

15

1.214 (1.013–1.456) *

<0.001

15

1.388 (0.944–2.040)

<0.001

15

1.164 (0.938–1.444)

<0.001

15

1.208 (0.974–1.498)

<0.001

HWE

            

YES

24

1.125 (0.982–1.288)

<0.001

20

1.045 (0.871–1.253)

0.412

24

1.069 (0.896–1.275)

<0.001

24

1.103 (0.931–1.308)

<0.001

NO

13

1.280 (1.063–1.541) *

<0.001

13

1.553 (1.018–2.367) *

<0.001

13

1.386 (1.121–1.714) *

0.04

13

1.428 (1.151–1.772) *

0.012

  1. *Significant association; OR: odds ratio; CI: confident intervals; CRC: Colorectal Cancer; EC: Esophageal Cancer; GC: Gastric Cancer; HCC: Hepatocellular Carcinoma; HB: hospital-based; PB: population-based; Large: >500 participants; Small: <500 participants; HWE: Hardy-Weinberg equilibrium; YES: agreement with HWE; NO: disagreement with HWE.
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