Table 1 Representative differentially expressed genes that were significantly higher in preterm infants versus term infants
From: Non-invasive analysis of intestinal development in preterm and term infants using RNA-Sequencing
Category and Gene ID | Term (average FPKM) | Preterm (average FPKM) | Preterm/Term | p value (uncorrected) | Description |
|---|---|---|---|---|---|
Lipid Metabolism | Â | Â | Â | Â | Â |
ApoA4 | 483.85 | 18651.40 | 38.55 | 0.0001 | Lipid metabolism, chylomicron and VLDL secretion |
ApoA1 | 254.23 | 6906.41 | 27.17 | 0.0001 | Lipid metabolism, reverse cholesterol transport |
ASAH1 | 14.90 | 80.51 | 5.40 | 0.0064 | Acid ceramidase, mediates cell growth arrest, differentiation and apoptosis |
CERS2 | 92.13 | 371.37 | 4.03 | 0.0061 | Ceramide synthase 2, regulates cell growth |
MTM1 | 3.10 | 59.97 | 19.36 | 0.0037 | Lipid phosphatase that negatively regulates EGFR degradation |
PLIN2 | 127.72 | 359.13 | 2.81 | 0.0149 | Controls the levels of lipid droplets, regulation of colonic cell growth |
Immune | Â | Â | Â | Â | Â |
CASP1 | 128.56 | 888.21 | 6.91 | 0.0030 | Inflammasomes mediate activation of caspase 1 and promote secretion of IL-1beta and IL-18 |
IL1B | 2343.32 | 6974.19 | 2.98 | 0.0926 | Linked to intestinal disorders of inflammation in neonates |
ICAM1 | 34.94 | 112.40 | 3.22 | 0.0280 | Leukocyte trafficking across the endothelium |
IL33 | 10.52 | 61.12 | 5.81 | 0.0144 | Innate immune cell modulation, mediates Th2 immune response (parasite infections) |
LCP1 | 14.06 | 72.14 | 5.13 | 0.0081 | Associated with active Crohn's disease |
NFKBIA | 373.98 | 1164.21 | 3.11 | 0.0112 | Regulates many epithelial and immune cell functions |
PFKFB3 | 237.61 | 621.85 | 2.62 | 0.0271 | Gene target of PPARgamma, regulates diet induced intestine inflammation response |
S100-A9 | 71.14 | 1192.90 | 16.77 | 0.0043 | Calcium and zinc binding protein that regulates inflammatory and immune responses; functions extracellularly as an antimicrobial |
SOCS3 | 164.05 | 748.63 | 4.56 | 0.0017 | Suppressor of cytokine signaling, generally anti-inflammatory that limits IL-6 induction of STAT3 |
TREM-1 | 15.29 | 96.78 | 6.33 | 0.0172 | Expressed on myeloid cells (PMNs, monocytes/macrophages), increases with inflammatory diseases, linked to macrophage amplification of chronic inflammation |
TYROBP | 153.23 | 902.38 | 5.89 | 0.0067 | An adaptor protein associated with multiple cell surface activating receptors expressed on both lymphoid and myeloid lineages |
Cellular Function | Â | Â | Â | Â | Â |
CEBPB | 75.39 | 290.56 | 3.85 | 0.0098 | Transcription factor regulating keratin synthesis |
CFLAR | 30.29 | 139.71 | 4.61 | 0.0451 | Apoptosis regulatory protein, tissue homeostasis |
FAM65B | 9.00 | 169.30 | 18.81 | 0.0007 | Promotes myogenic differentiation and cytoskeletal rearrangement |
FUBP1 | 31.78 | 110.84 | 3.49 | 0.0128 | DNA binding protein that promotes c-myc expression |
G0S2 | 2927.30 | 60194.00 | 20.56 | 0.0003 | Promotes apoptosis, prevents bcl2-bax heterodimers |
KDM5B | 32.12 | 98.30 | 3.06 | 0.0281 | Histone demethylase, favors cell proliferation |
MMP1 | 53.25 | 159.15 | 2.99 | 0.0392 | Matrix metalloproteinase, potential regulator of intestinal homeostasis |
NPM1 | 59.07 | 165.49 | 2.80 | 0.0484 | Nucleolar acidic protein, plays a positive role in cell proliferation and growth |
SERPINA1 | 136.74 | 534.73 | 3.91 | 0.0012 | Serine protease inhibitor, proteolytic activity towards insulin, protects lower respiratory tract |
