Figure 1 | Scientific Reports

Figure 1

From: Disorganized vascular structures in sporadic venous malformations: a possible correlation with balancing effect between Tie2 and TGF-β

Figure 1

Detection and evaluation of perivascular α-SMA+ cell coverage in venous malformations (VMs).

(A) Double-labelling immunofluorescence for CD34 and α-SMA in VM and normal skin (SK) tissues. The fluorescence intensity of perivascular α-SMA is significantly decreased in VMs compared with that in the SK tissues. Nuclei are counterstained with Hoechst. (B) Double-labelling immunohistochemistry for CD34 and α-SMA in VM, SK, pyogenic granulomas (PG) and placenta (PL) tissues. The arrows in the magnified images of (A) and (B) indicate the areas without vSMCs in VMs. (C) Quantification of perivascular α-SMA+ cell coverage in VM, SK, PG and PL tissues. Data are expressed as means ± SEM. **, P < 0.01 versus VM tissues.

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