Figure 4

Immunohistochemical staining to detect Tie2 expression and phosphorylation in venous malformations (VMs).
(A, C) Increased expression and phosphorylation of Tie2 are observed in VM tissues when compared with normal skin (SK) tissues. (B, D) Quantification of the expression and phosphorylation levels of Tie2 in VM and SK tissues. Data are expressed as means ± SEM. *, P < 0.05; ***, P < 0.001 versus SK tissues.