Figure 5 | Scientific Reports

Figure 5

From: An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E-/- mice

Figure 5

3BDO inhibited endothelium autophagy and apoptosis in apoE-/- mice.

(a), En face staining of LC3 patches (green) in the thoracic aorta endothelium of apoE-/- mice. Endothelial cells were marked with CD31 (red). Nucleus (blue) was stained with DAPI. Bar = 60 μM. (b), Quantification of LC3 dots in the thoracic aorta endothelium. Data are mean ± SEM. n = 6. (c), Sections from the mice aortic roots were labeled by TUNEL to detect apoptotic cells and counterstained with DAPI to detect nuclei. The arrows indicated the TUNEL-positive cells. Bar = 60 μM. (d), Quantification of TUNEL-positive cells in the plaque endothelium. Data are mean ± SEM. n = 6.

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