Figure 6 | Scientific Reports

Figure 6

From: An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E-/- mice

Figure 6

Effect of 3BDO on the phenotype of aortic atherosclerotic plaque in apoE-/- mice.

(a), Oil-red O staining of whole aortas and quantification. Data are mean ± SEM, Bar = 3 mm, n = 6. (b), Hematoxylin and eosin (H&E) staining and quantification of plaque area. Data are mean ± SEM. Bar = 500 μm. (c), From the top to bottom panel, Oil-red O staining of atherosclerotic lesions, immunofluorescence staining for mouse α-smooth muscle actin, Mac-3 (M3/84) and in situ zymography of matrix metalloproteinase 2/9 (MMP-2/9) activity. Bar for Oil-red O staining = 500 μm, others = 80 μm. D, Quantification of lipid area, smooth muscle area, macrophage area and MMP-2/9 activity in control and 3BDO-treated groups. Data are mean ± SEM. n = 6.

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