Figure 8 | Scientific Reports

Figure 8

From: An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E-/- mice

Figure 8

Conceptual schematic of 3BDO and mTOR action mechanism in atherosclerosis.

OxLDL could induce mTOR inhibition and the inhibition of mTOR contributes to autophagy by increasing the protein level of ATG13 and inhibiting ATG13 phosphorylation. The excessively stimulated autophagy finally leads to endothelial injury of apoE-/- mice. 3BDO could reverse oxLDL-induced mTOR inhibition in VECs and inhibit oxLDL-induced ATG13 increase and dephosphorylation, thus relieving oxLDL-induced autophagy injury and inhibiting atherosclerosis development in apoE-/- mice.

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