Table 1 Adrenergic, dopaminergic and serotonergic action of compounds applied in humans and insects

From: Disruption of aminergic signalling reveals novel compounds with distinct inhibitory effects on mosquito reproduction, locomotor function and survival

compound

function in humans

function in insects

Reference

Tyrosine

Precursor of DOPA, dopamine, adrenaline and noradrenaline

Precursor of DOPA, dopamine, tyramine and octopamine

[48]

L-DOPA

D(1-4) dopamine receptor agonist, dopamine precursor

Dopamine and DOPA melanin precursor,

[48,49,50]

Dopamine

D(1-4) dopamine receptor agonist, dopamine transport inducer, dopamine beta hydroxylase ligand,

dopamine melanin precursor, Dop1-3 receptor agonist, Oct α2R (OA3) agonist, TyR1 and TyR3 agonist

[27,29,30,38,51,52]

Carbidopa

Aromatic amino acid decarboxylase (AADC) inhibitor

DDC inhibitor

[53,54]

Tyramine

Trace amine associated receptor (TAAR) agonist, β-adrenergic receptor 1 and 2 (ADBR1,2) antagonist

Oct α2R (OA3) agonist, TyR1-3 agonist, Dop3 (D2 like) agonist

[29,30,38,45,55,56,57]

Octopamine

TAAR agonist, ADRB2-antagonist, ADRB1,3-agonist

Oct α2R (OA3) agonist, TyR 1 agonist, OctβR (OA2) agonist, TyR3 agonist

[29,30,38,57,58,59]

Clonidine

α2 adrenergic agonist

TyR > OctR agonist, Oct α2R (OA3) agonist, OctR 1 (OA1) agonist

[30,60,61]

Yohimbine

α2, 5-HT(1B), 5-HT(1D) and D(2) receptor antagonist, 5HT (1A) agonist

TyR 1 antagonist, 5-HT1,2,7 antagonist, OctR1 (OA1) antagonist, TyR>OctR antagonist

[28,30,45,61,62,63,64]

Prazosin

α1 antagonist

TyR1 (Oct/Tyr) antagonist, 5-HT1,7 antagonist, OctR antagonist

[58,61,65,66]

Phenylephrine

α1 agonist

TyR agonist, Oct R agonist

[67,68]

Clenbuterol

β2 agonist

ND

[69]

Dobutamine

β1 and α1 agonist

ND

[70]

Acebutolol

β1 antagonist

ND

[71]

Sotalol

Non-selective β- blocker

ND

[72]

Amitriptyline

Noradrenaline and serotonin transport (SERT) inhibitor, 5HT-2A receptor antagonist, TrkA and TrkB receptor agonist

Dop2 antagonist

[27,73,74,75,76,77]

Sch-39166 (Ecopipam)

D1 receptor antagonist

ND

[78]

SKF-38393

D1 receptor agonist

Dopamine 1 receptor (Dop1) agonist

[27,79]

Domperidone

D2,D3 receptor antagonist

Dop3 (D2 like) antagonist

[80,81]

Bromocriptine

D2,D3, 5-HT receptor agonist, α2-adrenergic, D1 receptor antagonist, inactivates dopamine D4 and 5-HT7 receptors

Dop3 (D2 like) agonist

[55,82,83]

Serotonin (5HT)

5-HT agonist

5HT1,2,7 agonist, Dop3 (D2 like) agonist

[55,61,63,66]

5-Methyl-N,N-dimethyltryptamine (5-MeO-DMT)

5-HT agonist

5-HT2 agonist

[63,84]

Ketanserin

5-HT antagonist

5-HT2 antagonist

[63,85]

Citalopram

SERT inhibitor

ND

[86]

  1. ND-not determined.
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